Research

We are interested in developing and optimizing the platform of spatial metabolomics imaging techniques, including single-cell MALDI-MSI metabolic profiling and 3D/4D spatial metabolomics by combining MALDI with other modalities.

Leveraging our Interdisciplinary Imaging Platform (IDIP) centered on MALDI mass spectrometry imaging and integrated with super-resolution microscopy, EM, AFM and TOF-SIMS, we aim to uncover the metabolic regulation underlying neural development and neurological diseases, and to elucidate the broader brain–body metabolic network.

We further explore interdisciplinary research of functional interactions between nanomaterials and biological system in the areas of self-assembling peptides and peptide based cell specific sensors, for their potential applications in biomedicine.